Gage Conference Muscle 2020

Tuesday 21^st April

9:00 - 10:45

9:30 – 10:15

Registration

Morning tea served

Gallery

Dining Hall

11.00 – 12:30

Welcome and Gage Lecture

Chair: Angela Dulhunty

11:00 – 11:30

11:30 – 12:30

Welcome and introduction

Gage Lecture – Nicole Beard

12:30 – 13:30

Lunch Served

Dining Hall

13:30 –15:10

Muscle disorders 1

Chair: Miranda Grounds

13:30 – 13:55

Peter Arthur

Biomarkers in biofluids for Duchenne Muscular Dystrophy

13:55 – 14:20

Connie Jackaman

Immune system and dysferlinopathy

14:20 – 14:45

Gina Ravenscroft

Genetics and physiology: unravelling neuromuscular disease

14:45 – 15:10

talks from rego requests

TBA

15:15 - 15:50

Afternoon tea. Dining Hall

15:50 – 18:00

Novel therapeutic targets in the diseased heart  

Chair: Jim Bell

15:50 – 16:15

Alex Pinto

High-dimensional profiling of cellular drivers of cardiac dysfunction

16:15 – 16:40

Lea Delbridge

Heart Failure with preserved Ejection Fraction – many mechanistic unknowns

16:40 – 17:05

Kate Weeks

Protein phosphatases as emerging drug targets for HF

17:05 – 17:30

Helena Viola

An alternative mechanism for regulation of mitochondrial energetics on the heart.

17:30 – 18:00

talks from rego requests

TBA

18:00 – 19:15

Dinner served

Dining Hall

19:15 – 21:15

Muscle Signalling

Chair: Mark Febbraio

19:15 – 19:40

Martin Whitham

Deciphering the biological relevance of circulating extracellular vesicles during exercise

19:40 – 20:05

Sarah Turpin-Nolan

Ceramides in Skeletal Muscle - regulation of insulin signalling

20:05 – 20:30

Stefan Wette

Implications in addressing the potential translocation of titin-linked mechanosensing proteins in human skeletal muscle

20:30 – 20:55

20:55 – 21:30

Matt Watt

talks from rego requests

Extracellular vesicle secretion from muscle with exercise”

21:30 – 23:00

Mixer

War Memorial Foyer

Wednesday 22^nd April

7:30 - 8:30

Breakfast Served

Dining Hall

9:00 – 10:15

RyRs from different perspectives

Chair: Bradley Launikonis

9:00 – 9:25

Bradley Launikonis

Sarcoplasmic reticulum-mitochondrial functional interactions in muscle

9:25 – 9:50

Razvan Cornea

FRET-Based Structural Readouts for Therapeutic Discovery Targeting Dysregulated RyR

9:50 – 10:15

Michelle Munroe

RyR2 clustering properties in human atrial fibrillation

10:15 – 10:45

Morning tea served

Dining Hall

10:45 – 12:30

Cellular mechanisms of cardiac arrhythmias

Chair: Nikki Beard

10:45 – 11:10

Kelly Smith

Aberrant cardiac development & adult disease

11:10 – 11:35

Jamie Vandenberg

Single cell heterogeneity and cardiac electrical signaling: implications for abnormal heart rhythms

11:35 – 12:00

James Bell

Cardiac adiposity & arrhythmia vulnerability

12:00 – 12:25

Peter Molenaar

Phosphodiesterase targets for the management of ventricular arrhythmias in heart failure patients

12:30 - 13:30

Lunch Served

Dining Hall

13:30 – 3-30

talks from rego requests Chair: TBA

13:30 – 13:45

13:45 – 15:00

15:00 – 15:15

15:15 - 17:00

Poster session and afternoon tea.

Dining Hall

17:00 – 19:00

Structural and functional exploits of the calcium release unit

Chair: Marco Casarotto

17:00 – 17:25

Marco Casarotto

Uncoupling mitochondria and Cav1.2 to prevent ischemia reperfusion injury

17:25 – 17:50

Dmitry Shishmarev

Unravelling Molecular Mechanisms of Skeletal Excitation-Contraction Coupling Using NMR

17:50 – 18:15

Emily Rowland

Is it all starting to STACk up?

18:15 – 18:40

Robyn Rebbeck

Kinetics and Mapping of Ca-driven Structural Changes of Calmodulin Bound to Ryanodine Receptors

19:00 – 22:00

Conference Dinner

War Memorial Foyer and Dining Hall

Thursday 23^rd April

7:30 - 8:30

Breakfast Served

Dining Hall

9:00 – 10:30

Muscle disorders 2

Chair: Fran Evesson

9:00 – 9:15

Fran Evesson

Update and perspectives

9:15 – 9:40

Tamar Sztal

Uncovering the causes of muscle weakness in nemaline myopathy and identifying effective therapies

9:40 – 10:05

Joe Yasa

Interrogating the role of dysferlin exon-40a in muscle membrane repair and muscular dystrophy

10:05 – 10:30

Andrew Bjorksten

TBA

10:30 – 11:00

Morning tea served

Dining Hall

11:00 – 12:35

Muscle Metabolism

Chair: Robyn Murphy

11:00– 11:25

Magda Montgomery

Understanding the endocrine function of the heart – Is mitochondrial dysfunction a contributor to cardiokine secretion?

11:25 – 11:50

Nigel Turner

Sphingolipids and muscle metabolism

11:50 – 12:15

Jacqueline Stoecklii

TBA

12:15 – 12-40

Anna Calkin

TBA

12:40 - 13:30

Lunch Served

Dining Hall

13:30 – 14:35

Ca²⁺ signalling

Chair: Angela Dulhunty

13:30 – 13:55

Derek Laver

Phenytoin reduces activity of RYR2 – A potential mechanism for its cardioprotective action

13:55 – 14:20

Pete Jones

Relationship between RyR2 expression, clustering and function

14:20 – 14:45

Amanda Denniss

Dysregulation of atrial Ca²⁺ handling in the failing heart.

14:45 – 15:00 Prizes and Closing